Common Name(s): Methyl estradiolpropanoate,estradiol methyl propanoate
DESCRIPTION
What It Does: Regulated hormonal ingredient — prohibited in cosmetics in eu, us, canada, and most major markets.
Why It's Used: Estradiol esters have estrogenic activity; their use in cosmetics is restricted under eu cosmetics regulation 1223/2009 and similar regulations worldwide.
How It Works: Estradiol ester provides topical estrogenic hormone delivery; prohibited in cosmetics in most jurisdictions due to endocrine disruption and systemic hormonal effect concerns.
Typically Found In: Not for cosmetic use — prohibited/restricted in most markets
TECHNICAL DETAILS
Primary Category: Restricted — prohibited in most cosmetic applications
Secondary Functions: Not applicable — not for cosmetic use
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: Do not use
SOURCING & ETHICS
Vegan Status: Conditional - supplier confirmation required
Halal Status: Unverified - supplier confirmation required
Source Notes: Prohibited in eu cosmetics (annex ii); restricted in us and canada; do not use in cosmetics without thorough regulatory review. [audit 2026-07-29 rev2: the record's own source_notes does not assert a non-animal origin, or instructs the reader to verify with the supplier; "yes" asserts knowledge the record does not hold. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 2026-02-05 00:00:00 -0800
Comedogenicity Rating: 2026-01-05 00:00:00 -0800
Sensitivity Concerns: Significant endocrine disruption risk at cosmetic use levels; not recommended.
Safe for Sensitive Skin: Not recommended
SAFETY & COMPATIBILITY
Safety Profile: Prohibited in eu, us, canada cosmetic applications. consult regulatory authority.
Works Well With: N/a — avoid cosmetic use
Avoid Combining With: Avoid in cosmetics — hormonal activity is prohibited in cosmetic formulations in most jurisdictions
SCIENTIFIC NOTE
Estradiol and its esters are annex ii prohibited substances in eu cosmetics regulation; classified as endocrine disruptors at cosmetic use levels; strongly discouraged even where not explicitly prohibited.
Last Verified: 2026-03-28
Primary Sources: Eu cosmetics regulation 1223/2009 annex ii,fda cosmetics regulations,cosing database