Common Name(s): Methylsilanol glycyrrhizinate,methylsilanol glycyrrhizinate,methylsilanol-active conjugate,silicon-delivered glycyrrhizin active

CAS Number: N/a

DESCRIPTION

What It Does: Delivers glycyrrhizin through methylsilanol-mediated sc penetration enhancement — the organosilanol carrier providing silicon-oxygen sc affinity for improved delivery depth versus free glycyrrhizin.

Why It's Used: Methylsilanol esters provide a unique penetration enhancement mechanism — the si-o-c bonds have affinity for the sc protein keratin's si-o-compatible surface, providing anchoring and gradual release for enhanced tissue delivery.

How It Works: Methylsilanol (si-oh): forms reversible si-o bonds with sc keratin protein hydroxyls → carrier anchoring → slow hydrolysis releases free active (theophylline/glycyrrhizin/spirulina extract) → local high concentration at the sc-dermis interface. spirulina phycocyanin: antioxidant + ho-1 upregulation.

Typically Found In: Anti-cellulite,anti-inflammatory,antioxidant

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Typical Concentration Range: 0.1%–2%

SOURCING & ETHICS

Vegan Status: Conditional - supplier confirmation required

Halal Status: Unverified - supplier confirmation required

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier. [audit 2026-07-29 rev2: the record's own source_notes does not assert a non-animal origin, or instructs the reader to verify with the supplier; "yes" asserts knowledge the record does not hold. determination requires shariah-panel sign-off.]

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Methylsilanol penetration mechanism: the organosilanol's affinity for hydroxyl-rich proteins in the sc provides substantivity enabling sustained release from the sc surface — different from conventional sc lipid-phase penetration enhancers.

Last Verified: 2026-03-22

Primary Sources: Cosing database,methylsilanol glycyrrhizinate methylsilanol enhanced delivery review