Common Name(s): Minoxidil succinoyl decapeptide-18,minoxidil succinoyl decapeptide-18,minoxidil-peptide conjugate,hair growth drug-peptide hybrid

CAS Number: N/a

DESCRIPTION

What It Does: Provides minoxidil's documented hair follicle katp channel-opening hair growth stimulation combined with signal peptide receptor-mediated hair growth signalling — dual-mechanism hair loss treatment from one conjugated molecule.

Why It's Used: Minoxidil is the only fda-approved otc drug for androgenetic alopecia with established clinical efficacy — the peptide conjugation aims to add complementary signal peptide hair growth receptor pharmacology to the established minoxidil mechanism.

How It Works: Minoxidil: katp channel opening → kir6.1/sur1 subunit → membrane hyperpolarisation → reduced ca²⁺ influx → follicle vasodilation + pge2 synthesis → hair follicle growth stimulation. signal peptide → hair growth receptor (wnt/β-catenin, fgf, igf-1) → hair follicle proliferation. succinoyl linker hydrolysis releases both components for independent receptor engagement.

Typically Found In: Hair growth,anti-hair loss

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Typical Concentration Range: Check otc drug classification

SOURCING & ETHICS

Vegan Status: Conditional - supplier confirmation required

Halal Status: Unverified - supplier confirmation required

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier. [audit 2026-07-29 rev2: the record's own source_notes does not assert a non-animal origin, or instructs the reader to verify with the supplier; "yes" asserts knowledge the record does not hold. determination requires shariah-panel sign-off.]

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Regulatory classification: minoxidil is an otc drug in the us (2% women, 5% men), uk, and many markets — its conjugate would require regulatory classification assessment in each market. drug classification is likely given minoxidil's primary pharmacological mechanism is unchanged by peptide conjugation.

Last Verified: 2026-03-22

Primary Sources: Fda otc minoxidil monograph,cosing,minoxidil succinoyl decapeptide-18 drug classification review