Common Name(s): Mirodenafil,mirodenafil,pde5 inhibitor pharmaceutical,drug not cosmetic — prohibited

CAS Number: N/a

DESCRIPTION

What It Does: Prohibited in cosmetics. mirodenafil is a pharmaceutical pde5 inhibitor with primary pharmacological mechanism (cgmp-mediated vasodilation) classifying it as a drug in all major regulated markets.

Why It's Used: Pde5 inhibition with systemic vasodilation is an unambiguously pharmaceutical effect — the drug/cosmetic boundary is clearly crossed by a compound that affects smooth muscle function throughout the cardiovascular system.

How It Works: Mirodenafil: selective pde5 inhibition → reduced cgmp hydrolysis → elevated cgmp → pkg → smooth muscle relaxation → vasodilation. systemic vasodilation effects and interaction with nitrate medications constitute the pharmacological drug profile.

Typically Found In: Prohibited in cosmetics

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Typical Concentration Range: Prohibited

SOURCING & ETHICS

Vegan Status: Conditional - supplier confirmation required

Halal Status: Unverified - supplier confirmation required

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier. [audit 2026-07-29 rev2: the record's own source_notes does not assert a non-animal origin, or instructs the reader to verify with the supplier; "yes" asserts knowledge the record does not hold. determination requires shariah-panel sign-off.]

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Replace with cosmetic-classification vasodilators: niacin derivatives (butoxyethyl nicotinate), strontium chloride (for sensory modulation), or menthol/cooling agents for circulatory-sensation products within the cosmetic regulatory boundary.

Last Verified: 2026-03-22

Primary Sources: Eu regulation 1223/2009,mirodenafil pde5 pharmaceutical drug classification review