Common Name(s): Mulberroside a,mulberroside a,morus alba oxyresveratrol glucoside,potent tyrosinase inhibitor brightening

CAS Number: N/a

DESCRIPTION

What It Does: Provides the most potent tyrosinase inhibition of any characterised natural stilbene compound — mulberroside a's ic50 of 0.4 μm for tyrosinase cu²⁺ chelation delivering effective brightening at cosmetically practical concentrations.

Why It's Used: Mulberroside a's resorcinol-catechol structural combination in the oxyresveratrol aglycone provides optimal tyrosinase active-site geometry for cu²⁺ chelation — the 4'-hydroxyl and 3,5-resorcinol positioning both catecholate groups for bidentate copper coordination.

How It Works: Mulberroside a glucoside → skin glucosidase → oxyresveratrol + glucose. oxyresveratrol catechol+resorcinol bidentate cu²⁺ chelation: both hydroxyl pairs coordinate the tyrosinase dinuclear cu₂ site (competitive inhibition, ic50 ~0.4 μm, 25× more potent than kojic acid 10 μm). glucoside maintains stability versus labile aglycone while skin enzyme releases active.

Typically Found In: Brightening,anti-aging,premium actives

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Typical Concentration Range: 0.01%–1%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Mulberroside a concentration-activity: at ic50 ~0.4 μm (~0.02%), mulberroside a provides significant tyrosinase inhibition — clinical brightening at 0.1-1% provides 5-50× the ic50 ensuring near-complete enzyme inhibition at the melanogenesis site.

Last Verified: 2026-03-22

Primary Sources: Cosing database,mulberroside a oxyresveratrol morus alba tyrosinase review