Common Name(s): Myristoyl pentapeptide-16,myristoyl pentapeptide-16,myristoyl-anchored signal peptide,lipid-penetrating anti-aging active
CAS Number: N/a
DESCRIPTION
What It Does: Delivers anti-aging signal peptide activity to the dermis through myristoyl c14 anchor sc penetration โ activating fibroblast collagen synthesis and mmp inhibition receptors that surface-retained sequences cannot access.
Why It's Used: Myristoyl anchoring is the primary penetration enhancement strategy for cosmetic peptides โ c14 myristic acid raises logp by ~3.5 providing sc lipid-phase partitioning unavailable to water-soluble unanchored peptides.
How It Works: Myristoyl amide bond: tissue amidase resistance (slower hydrolysis than ester) + c14 chain logp contribution ~+3.5 โ sc lipid bilayer intercalation โ peptide transport to dermis. active sequence: receptor binding โ tgf-ฮฒ/integrin โ smad2/3 โ col1a1/eln upregulation. myristoyl-anchored peptides reach 3-5ร deeper dermis versus non-anchored equivalents.
Typically Found In: Anti-aging serums,collagen products
TECHNICAL DETAILS
Primary Category: Active ingredient โ peptide
Secondary Functions: Collagen synthesis,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 1โ5000 ppm
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Synthetically produced via solid-phase peptide synthesis (spps).
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating at recommended concentrations.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid
Avoid Combining With: Strong acids below ph 3.5; oxidising agents
SCIENTIFIC NOTE
Myristoyl chain length comparison: c14 (myristoyl) provides 3.5 logp units โ intermediate between c12 (lauroyl, 3.0) and c16 (palmitoyl, 4.0). the c14 chain provides the optimal balance between sc penetration depth (favours longer chain) and aqueous formulation miscibility (favours shorter chain).
Last Verified: 2026-03-22
Primary Sources: Cosing database,myristoyl pentapeptide-16 myristoyl peptide anti-aging review