Common Name(s): N-linolenoyl serinol,n-linolenoyl serinol,n-acyl serinol,ceramide precursor sphingolipid

CAS Number: N/a

DESCRIPTION

What It Does: Integrates into sc lamellar lipid bilayers as a ceramide structural analogue — restoring the ceramide fraction depleted in dry and atopic skin, and serving as a direct substrate for ceramide biosynthesis enzyme (serine palmitoyl transferase pathway).

Why It's Used: N-acyl sphingolipid and serinol derivatives provide the most direct sc ceramide restoration — the sphingolipid architecture enabling genuine lamellar bilayer participation for barrier repair.

How It Works: N-acyl serinol: amide-linked fatty acid (c18 stearoyl, c18:2 linoleoyl, or c18:3 linolenoyl) provides the sc lamellar integration geometry. tissue ceramide synthase (cers) can utilise the preformed n-acyl sphingolipid directly in the ceramide synthesis pathway, providing both topical emolliency and intracellular ceramide biosynthesis support.

Typically Found In: Barrier repair,eczema care,ceramide skin care

TECHNICAL DETAILS

Primary Category: Functional ingredient – emollient

Secondary Functions: Barrier sealing,softening

Application Areas:

Typical Concentration Range: 0.1%–3%

SOURCING & ETHICS

Vegan Status: Conditional - supplier confirmation required

Halal Status: Unverified - supplier confirmation required

Source Notes: Plant-derived, synthetic or animal-derived. verify source. [audit 2026-07-29 rev2: the record's own source_notes does not assert a non-animal origin, or instructs the reader to verify with the supplier; "yes" asserts knowledge the record does not hold. determination requires shariah-panel sign-off.]

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 1/5 – low; formulation-dependent

Sensitivity Concerns: Non-irritating.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Humectants,ceramides,actives as carrier

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Fatty acid selection determines barrier and anti-inflammatory profile: stearoyl (c18:0) → structural ceramide replacement; linoleoyl (c18:2) → ceramide 1 acylceramide precursor (critical for lamellar body formation); linolenoyl (c18:3 omega-3) → anti-inflammatory eicosanoid competition.

Last Verified: 2026-03-22

Primary Sources: Cosing database,n-linolenoyl serinol ceramide precursor sphingolipid barrier review