Common Name(s): Neem leaf extract,indian lilac extract

CAS Number: 84696-19-5

DESCRIPTION

What It Does: Provides nimbin anti-inflammatory and nimbidin antimicrobial activity for acne and inflammatory skin conditions.

Why It's Used: Multi-function ayurvedic anti-acne and anti-inflammatory from neem with comprehensive antimicrobial and anti-inflammatory activity.

How It Works: Nimbin inhibits phospholipase a2 for arachidonic acid cascade anti-inflammatory activity. nimbidin provides antimicrobial activity vs p. acnes and s. aureus. nimbidiol inhibits histamine release for anti-allergic activity.

Typically Found In: Anti-acne products,ayurvedic formulations,antimicrobial skin care

TECHNICAL DETAILS

Primary Category: Active ingredient – soothing / anti-inflammatory

Secondary Functions: Redness reduction,anti-inflammatory,calming

Application Areas:

Typical Concentration Range: 0.1%–5%

SOURCING & ETHICS

Vegan Status: Yes – from azadirachta indica leaves

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; ideal for reactive and sensitive skin.

Safe for Sensitive Skin: Yes – particularly recommended for sensitive skin

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,panthenol,allantoin,hyaluronic acid,centella asiatica

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Neem's phospholipase a2 inhibition provides anti-inflammatory activity at the most upstream point of the arachidonic acid cascade – before arachidonic acid is even released from membrane phospholipids, preventing the entire downstream cox and lox inflammatory pathway. this upstream inhibition provides theoretically more comprehensive inflammation prevention than cox or lox inhibitors acting downstream.

Last Verified: 2026-03-12

Primary Sources: Cosing database,subapriya & nagini neem review