Common Name(s): Neohesperidin,neohesperidin,bitter orange flavanone glycoside,sweetness modifier anti-inflammatory active
CAS Number: N/a
DESCRIPTION
What It Does: Provides bitter taste masking for oral care and edible cosmetics through t2r receptor competitive antagonism, anti-inflammatory cox-1/2 and 5-lox inhibition from the flavanone catechol, and antioxidant radical scavenging.
Why It's Used: Neohesperidin's rutinose (neohesperidoside) linkage is specifically recognised by t2r bitter receptors as a partial agonist that blocks full agonist access โ providing bitter masking at concentrations below the receptor saturation threshold.
How It Works: Neohesperidin t2r competitive antagonism: neohesperidoside sugar geometry fits the t2r38/t2r14 bitter receptor binding site as partial agonist โ blocks full agonist (caffeine, quinine, isohumulones) access โ bitter taste reduction. flavanone chromophore: cox-1/2 competitive inhibition (ic50 ~15 ฮผm); catechol b-ring radical h-atom donation.
Typically Found In: Oral care,anti-inflammatory,bitter masking
TECHNICAL DETAILS
Primary Category: Active ingredient โ antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01%โ2%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Neohesperidin vs naringenin: both flavanones provide anti-inflammatory activity but neohesperidin's neohesperidoside linkage provides the bitter-masking activity absent in naringenin's glucoside form โ the specific sugar linkage geometry determines the t2r receptor interaction.
Last Verified: 2026-03-22
Primary Sources: Cosing database,neohesperidin bitter masking anti-inflammatory review