Common Name(s): Neoruscogenin,neoruscogenin,ruscus spirostanol saponin aglycone,anti-oedema vascular active
CAS Number: N/a
DESCRIPTION
What It Does: Provides vascular smooth muscle contraction through alpha-1 adrenergic receptor agonism to reduce periorbital puffiness and leg oedema, inhibits hyaluronidase protecting capillary basement membrane integrity, and modulates nf-kb for anti-inflammatory support.
Why It's Used: Neoruscogenin's alpha-1 adrenergic agonism provides the most physiologically direct anti-oedema mechanism โ activating the same receptor as endogenous norepinephrine for vein smooth muscle contraction that reduces the venous pooling causing periorbital puffiness and leg heaviness.
How It Works: Neoruscogenin spirostanol ring: alpha-1 adrenergic receptor partial agonism (kd ~500 nm) โ gq-plc โ ip3 โ caยฒโบ โ vein smooth muscle contraction โ reduced venous pooling โ decreased oedema. hyaluronidase inhibition (ic50 ~50 ฮผm): saponin competitive inhibition protecting vascular basement membrane ha from enzymatic degradation.
Typically Found In: Anti-puffiness,vascular skin care,leg care
TECHNICAL DETAILS
Primary Category: Active ingredient โ antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01%โ1%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Butcher's broom pharmaceutical use: ruscus aculeatus extract (standardised to ruscogenins) is approved as a medicine for chronic venous insufficiency in several eu markets โ the same vascular pharmacology applicable to cosmetic anti-oedema and anti-puffiness claims at cosmetic concentrations.
Last Verified: 2026-03-22
Primary Sources: Cosing database,neoruscogenin ruscus alpha-1 adrenergic anti-oedema review