Common Name(s): Nmn,beta-nicotinamide mononucleotide,nad+ precursor

CAS Number: 1094-61-7

DESCRIPTION

What It Does: Provides the most direct nad+ precursor for efficient cellular nad+ replenishment and anti-aging sirtuin activation.

Why It's Used: Most efficient nad+ precursor – nmn requires only one biosynthetic step to nad+ (vs niacinamide's two steps), providing more efficient nad+ replenishment for sirtuin anti-aging pathway activation.

How It Works: Nampt-independent pathway: nmn is phosphorylated to nmnat by nmnat enzyme directly yielding nad+. bypasses the rate-limiting nampt step required by niacinamide/nr → nmn → nad+ pathway. faster nad+ elevation in cells for sirtuin substrate availability.

Typically Found In: Premium anti-aging serums,nad+ longevity products

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Direct nad+ precursor,nampt-independent,sirtuin substrate

Application Areas:

Typical Concentration Range: 0.01%–1%

SOURCING & ETHICS

Vegan Status: Conditional - supplier confirmation required

Halal Status: Unverified - supplier confirmation required

Source Notes: Highly unstable – rapidly hydrolyzed in aqueous conditions. requires encapsulation or anhydrous formulation. expensive vs niacinamide. [audit 2026-07-29 rev2: the record's own source_notes does not assert a non-animal origin, or instructs the reader to verify with the supplier; "yes" asserts knowledge the record does not hold. determination requires shariah-panel sign-off.]

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Nmn's one-step nad+ biosynthesis (nmn → nad+ via nmnat) vs niacinamide's two-step pathway (nicotinamide → nmn via nampt, then nmn → nad+) provides faster and more efficient intracellular nad+ elevation. the rate-limiting nampt enzyme (nicotinamide phosphoribosyltransferase) declines with age and inflammation, making the nampt-bypassing nmn pathway particularly advantageous in aged skin.

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