Common Name(s): Oleuropein aglycone,oleuropein aglycone,olive secoiridoid,potent anti-inflammatory anti-aging active
CAS Number: N/a
DESCRIPTION
What It Does: Provides potent nf-kb and cox-2 anti-inflammatory inhibition from the secoiridoid michael acceptor, exceptional antioxidant protection from the catechol enol (orac >70 ฮผmol te/mg), and tyrosinase cuยฒโบ chelation for brightening.
Why It's Used: Oleuropein aglycone is more potent than the glucoside form by 10-50ร โ the beta-glucosidase-released aglycone's enol tautomer providing the michael acceptor pharmacophore for covalent anti-inflammatory enzyme inhibition unavailable from the protected glucoside.
How It Works: Oleuropein โ beta-glucosidase โ oleuropein aglycone (1:1 mixture of dialdehydic and cyclic forms). aglycone michael acceptor: covalent ikk-ฮฒ cys179 adduct โ nf-ฮบb blocked; cox-2 active-site michael addition โ prostaglandin inhibition. catechol + enol: orac >70 ฮผmol te/mg. catechol cuยฒโบ chelation โ tyrosinase inhibition.
Typically Found In: Premium anti-inflammatory,brightening,anti-aging
TECHNICAL DETAILS
Primary Category: Active ingredient โ antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01%โ1%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Oleuropein vs hydroxytyrosol: oleuropein aglycone provides covalent anti-inflammatory inhibition (irreversible); hydroxytyrosol provides reversible radical scavenging. the combination provides complementary mechanisms โ covalent nf-kb inhibition + reversible antioxidant โ for comprehensive olive polyphenol anti-aging.
Last Verified: 2026-03-22
Primary Sources: Cosing database,oleuropein aglycone secoiridoid anti-inflammatory anti-aging review