Common Name(s): Oxidized glutathione
DESCRIPTION
What It Does: Brightens skin and fights oxidative stress through the glutathione redox cycle.
Why It's Used: Used for brightening and antioxidant protection via intracellular glutathione cycling.
How It Works: Gssg is reduced back to gsh by glutathione reductase in cells; elevated gsh inhibits tyrosinase reducing melanin; enhanced redox status protects against oxidative damage.
Typically Found In: Brightening serums,anti-aging products
TECHNICAL DETAILS
Primary Category: Active ingredient โ brightening
Secondary Functions: Skin conditioning agent,antioxidant,brightening active
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%โ2%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: From oxidation of reduced glutathione (yeast fermentation); naturally derived.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Generally well tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile. ewg score: 1.
Works Well With: Vitamin c,niacinamide,alpha-lipoic acid
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Glutathione (gsh/gssg redox pair) is the primary intracellular antioxidant; gssg topical application can support intracellular gsh cycling and tyrosinase-mediated brightening.
Last Verified: 2026-03-28
Primary Sources: Cosing database,inci dictionary