Common Name(s): Palmitoyl carnosine,palmitoyl carnosine,lipophilic carnosine,anti-glycation peptide ester

CAS Number: N/a

DESCRIPTION

What It Does: Provides carnosine anti-glycation carbonyl quenching and zinc/copper chelating antioxidant activity with c16 palmitoyl chain-enhanced sc lipid bilayer penetration.

Why It's Used: Palmitoyl carnosine is selected over free carnosine for sc delivery — the palmitoyl ester resolves carnosine's fundamental sc penetration barrier (the zwitterionic peptide cannot partition into the lipid bilayer), delivering anti-glycation activity to dermal fibroblasts where age accumulation drives wrinkle formation.

How It Works: Palmitoyl carnosine → sc lipid bilayer partitioning (c16 chain) → esterase hydrolysis → carnosine release → beta-alanyl-his carbonyl quenching (anti-glycation) + zn²⁺/cu²⁺ chelation (antioxidant) in dermis.

Typically Found In: Anti-aging,anti-glycation,premium serums

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Typical Concentration Range: 0.01%–2%

SOURCING & ETHICS

Vegan Status: Conditional - feedstock declaration required

Halal Status: Unverified - feedstock declaration required (plant, animal and petrochemical routes all exist)

Source Notes: Plant-derived extract or synthetic. [audit 2026-07-29 rev2: origin-dependent: the same inci exists in plant, animal and petrochemical versions and the name does not discriminate. determination requires shariah-panel sign-off.]

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Anti-glycation activity addresses the rate-limiting step in dermal aging — age crosslinks accumulate irreversibly in collagen and elastin, making prevention via carnosine carbonyl quenching more effective than reversal.

Last Verified: 2026-03-22

Primary Sources: Cosing database,palmitoyl carnosine lipophilic anti-glycation dipeptide review