Common Name(s): Argireline peptide plus,pal-vgvapg elastin peptide

CAS Number: 171263-26-6

DESCRIPTION

What It Does: Provides elastin receptor-mediated elastin synthesis stimulation for skin firming and elasticity improvement.

Why It's Used: Elastin-targeting signal peptide — palmitoyl hexapeptide-12's vgvapg elastin sequence stimulates elastin synthesis via the same receptor pathway triggered by natural elastin degradation products.

How It Works: Vgvapg is a natural elastin degradation fragment (matrikine) released during matrix remodelling. elastin receptor (galactoside-binding lectin/67kda ebp) binding triggers elastin synthesis upregulation in fibroblasts. palmitoyl chain provides skin penetration enhancement. complementary to collagen-stimulating peptides for comprehensive matrix restoration.

Typically Found In: Firming anti-aging products,elastin-stimulating serums

TECHNICAL DETAILS

Primary Category: Active ingredient – signal peptide

Secondary Functions: Collagen stimulation,skin firming,anti-aging

Application Areas:

Typical Concentration Range: 0.0001%–0.01%

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Synthetically produced by solid-phase peptide synthesis (spps). may be palmitoylated for stability.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Exceptional safety profile. ewg score: 1.

Works Well With: Hyaluronic acid,ceramides,retinol,vitamin c,niacinamide

Avoid Combining With: Avoid mixing with high-concentration ahas at same ph (may hydrolyze peptide bonds)

SCIENTIFIC NOTE

Vgvapg's elastin receptor binding mechanism was first characterised by mecham et al. (1989) — 10 years before the palmitoyl-conjugated cosmetic version was developed. the natural elastin degradation fragment's receptor signalling for elastin synthesis regulation was discovered in cardiovascular biology, and repurposed as a cosmetic signal peptide by adding the palmitoyl chain for skin penetration.

Last Verified: 2026-03-12

Primary Sources: Cosing database,mecham et al. vgvapg elastin receptor study