Common Name(s): Palmitoyl hyaluronate,palmitoyl hyaluronate,lipophilic hyaluronate,amphiphilic ha derivative

CAS Number: N/a

DESCRIPTION

What It Does: Provides hyaluronic acid water-binding humectancy with c16 palmitoyl chain anchoring in sc lipid bilayers for extended hydration retention unavailable from standard water-soluble sodium hyaluronate.

Why It's Used: Palmitoyl hyaluronate is selected for its amphiphilic sc-anchoring architecture — the palmitoyl chain inserts into sc lipid bilayers to immobilise the ha hydrator at sc depth, providing prolonged water retention versus surface-deposited ha that washes off with the first water exposure.

How It Works: Palmitoyl-ha: c16 chain → sc lipid bilayer insertion → ha hydrator anchored at depth → sustained water-binding; unmodified ha: surface deposition → rapid wash-off.

Typically Found In: Moisturiser,barrier care,anti-aging

TECHNICAL DETAILS

Primary Category: Active ingredient – humectant

Secondary Functions: Moisture retention,hydration

Application Areas:

Typical Concentration Range: 0.1%–5%

SOURCING & ETHICS

Vegan Status: Conditional - feedstock declaration required

Halal Status: Unverified - feedstock declaration required (plant, animal and petrochemical routes all exist)

Source Notes: Plant-derived or fermentation-produced. [audit 2026-07-29 rev2: origin-dependent: the same inci exists in plant, animal and petrochemical versions and the name does not discriminate. determination requires shariah-panel sign-off.]

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for sensitive skin.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,emollients,occlusives,barrier actives

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Palmitoyl modification raises ha's logp from <-5 to approximately +1, enabling the transition from purely hydrophilic surface deposition to amphiphilic sc penetration.

Last Verified: 2026-03-22

Primary Sources: Cosing database,palmitoyl hyaluronate amphiphilic ha lipophilic review