Common Name(s): Pal-gqpr,matrixyl 3000 component,palmitoyl gly-gln-pro-arg
CAS Number: N/a
DESCRIPTION
What It Does: Reduces inflammatory cytokine il-6, calms skin inflammation, and stimulates ecm components for anti-aging.
Why It's Used: Used as the anti-inflammatory component of matrixyl 3000 for complementary anti-aging via inflammation-driven aging pathway inhibition.
How It Works: Pal-gqpr mimics immunomodulatory beta-msh peptide. binds mc receptors reducing il-6, a pro-aging inflammatory cytokine that inhibits collagen synthesis. works synergistically with pal-kttks in matrixyl 3000.
Typically Found In: Anti-aging serums,anti-inflammatory formulations,redness relief with anti-aging benefits
TECHNICAL DETAILS
Primary Category: Active ingredient โ anti-inflammatory signal peptide
Secondary Functions: Il-6 reduction,anti-inflammatory signaling
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 50โ1000 ppm
SOURCING & ETHICS
Vegan Status: Conditional - supplier confirmation required
Halal Status: Unverified - supplier confirmation required
Source Notes: Synthesized by spps with palmitoyl esterification. commercially supplied as matrixyl 3000 with pal-kttks (sederma). [audit 2026-07-29 rev2: the record's own source_notes does not assert a non-animal origin, or instructs the reader to verify with the supplier; "yes" asserts knowledge the record does not hold. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; suitable for all skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Exceptional safety profile. ewg score: 1.
Works Well With: Hyaluronic acid,ceramides,retinol,vitamin c,niacinamide
Avoid Combining With: Avoid mixing with high-concentration ahas at same ph (may hydrolyze peptide bonds)
SCIENTIFIC NOTE
The pal-kttks + pal-gqpr combination in matrixyl 3000 addresses two complementary aging pathways simultaneously: collagen stimulation (pal-kttks) and inflammation-driven collagen suppression reduction (pal-gqpr), providing superior anti-aging efficacy vs either peptide alone.
Last Verified: 2026-03-12
Primary Sources: Cosing database,sederma matrixyl 3000 technical data,gorouhi & maibach peptide review