Common Name(s): Matrixyl synthe'6,lys-val-lys palmitoyl variant
CAS Number: 1447025-32-2
DESCRIPTION
What It Does: Provides simultaneous stimulation of 6 major skin matrix proteins for comprehensive anti-aging matrix restoration.
Why It's Used: The most comprehensive matrix-stimulating peptide โ matrixyl synthe'6's simultaneous upregulation of all six major skin matrix proteins provides more complete extracellular matrix restoration than any single-target peptide.
How It Works: Activates multiple fibroblast receptor pathways simultaneously. upregulates collagen i, iii, iv synthesis. stimulates fibronectin, laminin-5, and ha synthase (has2) expression. comprehensive matrix restoration reduces wrinkle depth from all collagen and ha-dependent skin architecture components.
Typically Found In: Premium anti-aging serums,comprehensive anti-aging products
TECHNICAL DETAILS
Primary Category: Active ingredient โ signal peptide
Secondary Functions: Collagen stimulation,skin firming,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.0001%โ0.01%
SOURCING & ETHICS
Vegan Status: Yes โ synthetic
Halal Status: Yes
Source Notes: Synthetically produced by solid-phase peptide synthesis (spps). may be palmitoylated for stability.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; suitable for all skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Exceptional safety profile. ewg score: 1.
Works Well With: Hyaluronic acid,ceramides,retinol,vitamin c,niacinamide
Avoid Combining With: Avoid mixing with high-concentration ahas at same ph (may hydrolyze peptide bonds)
SCIENTIFIC NOTE
Matrixyl synthe'6's six-protein stimulation was characterised by sederma's research demonstrating simultaneous mrna upregulation for all six matrix proteins in human skin explants. the breadth of matrix stimulation from a single tripeptide reflects the convergent gene regulation of extracellular matrix proteins โ many share common transcription factor binding sites (ap-1, sp1) allowing coordinated upregulation from a single signalling peptide.
Last Verified: 2026-03-12
Primary Sources: Cosing database,sederma matrixyl synthe'6 technical data