Common Name(s): Vitamin b5,d-pantothenic acid,pantothenate
CAS Number: 0137-08-06
DESCRIPTION
What It Does: Provides the active vitamin b5 form for coa synthesis and wound healing support.
Why It's Used: Active vitamin b5 for coa-dependent metabolic support โ pantothenic acid provides the most direct cellular coa substrate for energy metabolism and fatty acid synthesis compared to panthenol's pro-vitamin form.
How It Works: Direct pantothenic acid โ phosphopantothenate โ coa biosynthesis (3-step pathway). coa is the universal acyl-transfer carrier for fatty acid synthesis, beta-oxidation, and tca cycle. pantothenic acid at wound site supports accelerated keratinocyte migration and proliferation. higher wound healing efficacy than panthenol in some models.
Typically Found In: Wound healing products,vitamins in skin care
TECHNICAL DETAILS
Primary Category: Active ingredient โ vitamin b complex
Secondary Functions: Antioxidant cofactor,metabolic support
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.5%โ5%
SOURCING & ETHICS
Vegan Status: Yes โ fermentation or synthetic
Halal Status: Yes
Source Notes: Synthetically produced for cosmetic use.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; excellent tolerability.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Other b vitamins,niacinamide,antioxidant complexes
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Pantothenic acid vs panthenol in topical formulations represents a formulation trade-off: pantothenic acid is the active form requiring no conversion but is hygroscopic and may destabilise formulations; panthenol is the stable pro-vitamin form requiring oxidation to pantothenic acid in skin. for wound healing applications where maximal coa availability is needed, direct pantothenic acid provides faster substrate availability than the panthenolโpantothenate conversion pathway.
Last Verified: 2026-03-12
Primary Sources: Cosing database,cir safety assessment