Common Name(s): Pantothenoyl dipeptide-13,pantothenoyl dipeptide-13,pantothenic acid derivative,coa biosynthesis cofactor skin active
CAS Number: N/a
DESCRIPTION
What It Does: Provides pantothenic acid pathway support for coa biosynthesis enabling acetyl-coa energy production and ceramide fatty acid synthesis for sc barrier repair โ the vitamin b5 pathway substrate for comprehensive skin metabolic support.
Why It's Used: Pantothenic acid is rate-limiting for coa biosynthesis in skin โ topical b5 supplementation supports the coa pool required for fatty acid synthesis (barrier ceramide precursors), acetyl-coa metabolism (energy), and protein acetylation (gene regulation).
How It Works: Pantothenic acid โ pantothenate kinase (coa biosynthesis rate-limiting step) โ 4'-phosphopantothenate โ phosphopantetheine โ coa. coa roles in skin: acetyl-coa (tca energy); malonyl-coa (fatty acid synthesis โ ceramide precursors); palmitoyl-coa (direct ceramide spt synthesis); protein acetyltransferase substrate (epigenetic regulation).
Typically Found In: Skin conditioning,barrier support,anti-aging
TECHNICAL DETAILS
Primary Category: Active ingredient โ antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%โ5%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Panthenol (pro-vitamin b5) is the standard cosmetic b5 form โ the alcohol (panthenol) penetrates sc better than pantothenic acid, converting to pantothenic acid intracellularly. modified derivatives in this batch provide additional functional benefits beyond standard panthenol.
Last Verified: 2026-03-22
Primary Sources: Cosing database,pantothenoyl dipeptide-13 pantothenic acid coa biosynthesis review