Common Name(s): Perfluoromethylcyclohexane,perfluorocarbon compound,oxygen-carrying ultra-hydrophobic material

CAS Number: N/a

DESCRIPTION

What It Does: Perfluoromethylcyclohexane creates an ultra-hydrophobic and oleophobic surface on skin or hair when used in surface treatment formulations (repelling both water and oils), delivers dissolved oxygen to the skin surface at concentrations far exceeding water-based vehicles when used as an o₂-saturated emulsion component, and provides extremely low-friction, light-reflecting surface treatment from the near-zero surface energy of the fluorinated surface.

Why It's Used: Formulators choose perfluoromethylcyclohexane for specialised applications where standard ingredients cannot deliver the required performance: oxygen-delivery anti-aging formulations where the high o₂-carrying capacity (50× water) enables topical o₂ supplementation for wound healing and mitochondrial energy support; ultra-water-repellent surface coatings for waterproof make-up and long-wear formulas where the combined hydrophobic and oleophobic character prevents both water and oil-based product transfer; and as an ultra-inert emollient for hypoallergenic formulas where zero reactivity with skin proteins is required.

How It Works: Perfluoromethylcyclohexane functions through the unique electronic properties of the c–f bond: fluorine is the most electronegative element, creating a c–f bond dipole with electron density shifted towards f. in the perfluorocarbon molecule, the surrounding fluorine atoms create a dense, uniform electron cloud around the carbon backbone that repels both polar (water) and non-polar (oil) molecules — making pfcs uniquely both hydrophobic and oleophobic, while the lack of any c–h bonds eliminates the hydrogen-bonding interaction sites that make oils spread on skin. the c–f bond energy (120 kcal/mol vs c–h 99 kcal/mol) makes pfcs extraordinarily chemically stable — resistant to acids, bases, oxidants, and metabolic enzymes at the skin surface. for oxygen delivery, the electron-dense f-atmosphere around carbon chains creates a non-polar, low-dielectric environment that dissolves non-polar molecular o₂ extremely efficiently from henry's law — the same principle used in pfc blood substitutes for systemic o₂ transport.

Typically Found In: Oxygen delivery skin care,ultra-repellent long-wear make-up

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Conditional - supplier confirmation required

Halal Status: Unverified - supplier confirmation required

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier. [audit 2026-07-29 rev2: the record's own source_notes does not assert a non-animal origin, or instructs the reader to verify with the supplier; "yes" asserts knowledge the record does not hold. determination requires shariah-panel sign-off.]

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Perfluorocarbon o₂ solubility mechanism: o₂ is a non-polar molecule (zero dipole moment). henry's law o₂ solubility is inversely related to solvent cohesive energy density (ced). water has very high ced from h-bonding network, requiring significant energy to cavity-form for o₂ insertion → low o₂ solubility (8 mg/l). perfluorocarbons have near-zero ced from the weak, non-directional london dispersion forces between f-bearing chains → minimal energy required to cavity-form for o₂ → 50× higher o₂ solubility. this is the same physical chemistry principle behind pfc blood substitute o₂ transport (fluosol-da, oxygent) — applied topically in cosmetics at cosmetically safe non-systemic concentrations.

Last Verified: 2026-03-12

Primary Sources: Cosing database,perfluorocarbon o₂ solubility,pfc cosmetic application review