Common Name(s): Persea gratissima sterols,persea gratissima sterols,plant phytosterols,barrier lipid active
CAS Number: N/a
DESCRIPTION
What It Does: Provides beta-sitosterol and campesterol phytosterols for sc lipid bilayer intercalation, competitive 5-alpha reductase inhibition for sebum reduction, and membrane fluidity modulation for barrier repair.
Why It's Used: Persea gratissima sterols is selected for avocado phytosterols' dual barrier repair and sebum-regulatory pharmacology — the c29 sitosterol scaffold competes with testosterone at 5-alpha reductase more potently than cholesterol, providing barrier restoration and anti-androgenic sebum control in one natural lipid fraction.
How It Works: Beta-sitosterol: sc cholesterol site intercalation → barrier lipid restoration; 5α-reductase competitive inhibition (ki ~15 μm) → reduced dht → sebum normalisation; nf-kb → anti-inflammatory.
Typically Found In: Barrier care,anti-acne,anti-aging
TECHNICAL DETAILS
Primary Category: Active ingredient – antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%–5%
SOURCING & ETHICS
Vegan Status: Conditional - feedstock declaration required
Halal Status: Unverified - feedstock declaration required (plant, animal and petrochemical routes all exist)
Source Notes: Plant-derived extract or synthetic. [audit 2026-07-29 rev2: origin-dependent: the same inci exists in plant, animal and petrochemical versions and the name does not discriminate. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Avocado phytosterols provide the highest beta-sitosterol content among plant oils — the unsaponifiable fraction is standardised to sterol content for consistent barrier and sebum-regulatory activity.
Last Verified: 2026-03-22
Primary Sources: Cosing database,persea gratissima sterols phytosterol barrier lipid review