Common Name(s): Apple dihydrochalcone,2,4,4',6'-tetrahydroxydihydrochalcone

CAS Number: 60-82-2

DESCRIPTION

What It Does: Provides glut-1 mediated anti-glycation alongside antioxidant and brightening activity.

Why It's Used: Anti-glycation antioxidant — phloretin uniquely inhibits glut-1 glucose transporter reducing dermal glucose penetration to prevent age formation in skin collagen.

How It Works: Glut-1 inhibition reduces glucose uptake into dermis for anti-glycation. tyrosinase inhibition provides brightening. antioxidant via chalcone radical scavenging. inhibits nf-kb for anti-inflammatory activity.

Typically Found In: Anti-glycation products,brightening serums,anti-aging

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Typical Concentration Range: 0.1%–2%

SOURCING & ETHICS

Vegan Status: Conditional - supplier confirmation required

Halal Status: Unverified - supplier confirmation required

Source Notes: Plant-derived extract or synthetic. [audit 2026-07-29 rev2: status downgraded on audit. determination requires shariah-panel sign-off.]

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Phloretin's glut-1 inhibition targets glycation at its source: glucose must enter the dermis via glut transporters before glycating collagen. by inhibiting glut-1, phloretin reduces the substrate available for glycation reactions — preventing age formation rather than reversing already-formed ages.

Last Verified: 2026-03-12

Primary Sources: Cosing database,wu et al. phloretin glut-1 study