Common Name(s): Phosphatidylserine,anionic cell membrane phospholipid,anti-aging membrane lipid
CAS Number: N/a
DESCRIPTION
What It Does: Replenishes age-depleted phosphatidylserine in cell membranes, activates pkc-ฮฑ and pkc-ฮฒ for keratinocyte differentiation and barrier gene upregulation, and provides biomimetic emolliency from the skin-identical phospholipid structure.
Why It's Used: Ps addresses the membrane lipid composition anti-aging mechanism that conventional actives cannot target โ direct restoration of a specific cell membrane lipid whose decline directly impairs skin cell signalling and barrier function.
How It Works: Ps's serine head group provides the anionic charge required for pkc membrane recruitment and activation โ pkc requires ps for full enzymatic activity regulating keratinocyte differentiation and barrier gene expression (involucrin, loricrin, filaggrin). ps also serves as 'find-me' apoptotic signal modulating inflammatory clearance.
Typically Found In: Premium anti-aging,cell membrane support
TECHNICAL DETAILS
Primary Category: Functional ingredient โ emollient
Secondary Functions: Barrier sealing,softening
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%โ2%
SOURCING & ETHICS
Vegan Status: Conditional
Halal Status: Conditional
Source Notes: Plant-derived, synthetic or animal-derived. verify source.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 1/5 โ low; formulation-dependent
Sensitivity Concerns: Non-irritating.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Humectants,ceramides,actives as carrier
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Plant-derived ps (sunflower/soy lecithin fractionation) is preferred over bovine brain ps (bse safety concerns) โ soy and sunflower ps provide identical molecular structure at lower ps content per gram than animal sources.
Last Verified: Cosing database,phosphatidylserine cell membrane anti-aging review
Primary Sources: 2026-03-12