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Common Name(s): Phytoecdysteroids,phytoecdysteroids,plant steroid hormones,erฮฒ protein synthesis anti-aging actives

CAS Number: N/a

DESCRIPTION

What It Does: Stimulates protein synthesis through erฮฒ receptor activation without classical estrogenic effects, upregulates collagen synthesis for anti-aging, and provides antioxidant protection โ€” the plant steroid's unique anabolic mechanism distinguishing it from both phytoestrogens and mammalian steroids.

Why It's Used: Phytoecdysteroids are unusual erฮฒ ligands โ€” the polyhydroxylated steroidal structure activates erฮฒ at kd ~100 nm without significant erฮฑ activity, providing anabolic protein synthesis without the reproductive hormonal effects of classical estrogens.

How It Works: 20-hydroxyecdysone erฮฒ binding (polyhydroxyl steroid, c-20 oh provides receptor contact) โ†’ nuclear erฮฒ โ†’ gre-like response elements โ†’ protein synthesis gene activation. collagen: smad-adjacent pathway โ†’ col1a1 upregulation. antioxidant: polyhydroxyl groups donate h-atoms to ros analogous to polyol antioxidants.

Typically Found In: Anti-aging,muscle-skin cross,anabolic skin care

TECHNICAL DETAILS

Primary Category: Active ingredient โ€“ antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.01%โ€“1%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 0/5 โ€“ non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Phytoecdysteroid regulatory note: 20-hydroxyecdysone is classified as a food supplement in some markets โ€” verify cosmetic ingredient classification in target markets as the anabolic protein synthesis mechanism may trigger drug/cosmetic boundary review in certain jurisdictions.

Last Verified: 2026-03-22

Primary Sources: Cosing database,phytoecdysteroids 20-hydroxyecdysone erฮฒ anabolic anti-aging review