Common Name(s): Placental protein,placental extract,growth factor-rich peptide complex,anti-aging wound healing
CAS Number: N/a
DESCRIPTION
What It Does: Delivers multiple growth factors for simultaneous collagen synthesis stimulation (egf/fgf fibroblast activation), keratinocyte renewal (egf receptor activation), and barrier repair (tgf-beta keratinocyte differentiation) — the multi-gf profile addressing all anti-aging cellular pathways concurrently.
Why It's Used: Placental extract is the only natural source providing clinically significant concentrations of multiple growth factors in a single ingredient — the combination of egf, fgf, igf-1, and tgf-beta provides synergistic anti-aging activity that individual growth factor supplements cannot replicate.
How It Works: Placental growth factors: egf binds egfr → erk1/2/mapk → keratinocyte proliferation; bfgf binds fgfr → pi3k-akt → fibroblast proliferation and col1a1 upregulation; igf-1 binds igf-1r → akt → protein synthesis; tgf-beta binds tgf-betar → smad2/3 → elastin and fibronectin synthesis. simultaneous multi-pathway activation provides comprehensive anti-aging matrix remodelling.
Typically Found In: Premium anti-aging,wound healing,k-beauty
TECHNICAL DETAILS
Primary Category: Active ingredient – antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%–10%
SOURCING & ETHICS
Vegan Status: No - human-derived
Halal Status: No - human-derived; majority prohibition (juz' al-adami) - panel confirmation required
Source Notes: Plant-derived extract or synthetic. [audit 2026-07-29 rev2: name declares human tissue, fluid or cell culture. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Placental extract regulatory status: sourcing from pig (sus scrofa) or horse (equus caballus) placentas requires compliance with bse/transmissible spongiform encephalopathy (tse) regulations in eu markets. certificate of origin and tse compliance documentation is mandatory for all animal-derived placental extracts.
Last Verified: 2026-03-22
Primary Sources: Cosing database,placental extract growth factor anti-aging review