Common Name(s): Vitamin b6,pyridoxol hydrochloride
CAS Number: 58-56-0
DESCRIPTION
What It Does: Regulates sebum production, conditions skin, reduces inflammation via amino acid metabolism.
Why It's Used: Used in oily and acne-prone products for sebum-regulating properties via potential 5-alpha-reductase inhibition.
How It Works: Converted to plp (pyridoxal-5-phosphate), cofactor for 100+ enzymes. may inhibit 5-alpha-reductase, reducing dht production stimulating sebaceous glands.
Typically Found In: Oily skin treatments,acne formulations,scalp treatments
TECHNICAL DETAILS
Primary Category: Active ingredient โ vitamin b6
Secondary Functions: Sebum control,scalp health
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%โ2%
SOURCING & ETHICS
Vegan Status: Yes โ synthetically produced
Halal Status: Yes
Source Notes: Synthetically produced for cosmetic use.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; excellent tolerability.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Other b vitamins,niacinamide,antioxidant complexes
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
5-alpha-reductase inhibition reduces testosterone-to-dht conversion, directly reducing androgen-driven sebaceous gland activity โ a meaningful mechanism for oily/acne-prone formulations.
Last Verified: Cosing database,cir safety assessment,scheinfeld et al. b vitamin dermatology review
Primary Sources: 2026-03-12