Common Name(s): R-clostridium histolyticum collagenase h,r-clostridium histolyticum collagenase h,recombinant clostridium collagenase,precision matrix remodelling drug-adjacent active
CAS Number: N/a
DESCRIPTION
What It Does: Provides precise collagenase-mediated collagen dissolution for scar tissue remodelling, dupuytren's contracture treatment, and deep dermal matrix remodelling โ the fda-approved mechanism for soft tissue collagen dissolution.
Why It's Used: Recombinant collagenase provides the most targeted collagen dissolution available โ the xen-type collagenase cleavage of collagen at specific gly-pro sequences provides surgical-precision matrix remodelling.
How It Works: R-collagenase: recombinant expression of c. histolyticum class i/ii collagenase โ zinc metalloprotease โ cleavage at gly-x-x motifs in collagen triple helix โ fibril dissolution.
Typically Found In: Regulatory review required โ drug classification likely
TECHNICAL DETAILS
Primary Category: Active ingredient โ peptide
Secondary Functions: Collagen synthesis,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: Verify regulatory classification
SOURCING & ETHICS
Vegan Status: Conditional
Halal Status: Conditional
Source Notes: Synthetically produced via solid-phase peptide synthesis (spps).
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating at recommended concentrations.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid
Avoid Combining With: Strong acids below ph 3.5; oxidising agents
SCIENTIFIC NOTE
Regulatory note: recombinant collagenase (xiaflex/xiapex) is fda/ema-approved as a pharmaceutical drug. recombinant botulinum components are pharmaceuticals. their use in cosmetics requires comprehensive regulatory boundary assessment โ these actives likely require pharmaceutical classification in most major markets.
Last Verified: Fda xiaflex approval,ema pharmaceuticals,r-clostridium histolyticum collagen drug-cosmetic classification review
Primary Sources: 2026-03-22