Back to Ingredient Dictionary

Common Name(s): R-(methionyl sh-polypeptide-10 decapeptide-40),r-(methionyl sh-polypeptide-10 decapeptide-40),recombinant multi-organism signal peptide complex,precision anti-aging active

CAS Number: N/a

DESCRIPTION

What It Does: Provides synergistic multi-receptor anti-aging activity from the combined peptide sequences โ€” targeting tgf-ฮฒ, egf, integrin, and other collagen synthesis receptors simultaneously for superior anti-aging outcomes versus single-sequence peptides.

Why It's Used: Multi-sequence peptide complexes provide receptor synergy unavailable from individual sequences โ€” simultaneous activation of complementary collagen synthesis pathways provides additive to super-additive anti-aging response.

How It Works: Recombinant expression system: heterologous host (saccharomyces, mussel, trypanosoma, bovine, mouse, thermophile) โ†’ ribosomal translation of synthetic gene encoding fused peptide sequences โ†’ affinity purification โ†’ cosmetic-grade active. individual sequences activate complementary receptors โ†’ convergent downstream signalling โ†’ col1a1/col3a1 upregulation.

Typically Found In: Premium anti-aging,collagen products

TECHNICAL DETAILS

Primary Category: Active ingredient โ€“ peptide

Secondary Functions: Collagen synthesis,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1โ€“5000 ppm

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Conditional

Source Notes: Synthetically produced via solid-phase peptide synthesis (spps).

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 0/5 โ€“ non-comedogenic

Sensitivity Concerns: Non-irritating at recommended concentrations.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid

Avoid Combining With: Strong acids below ph 3.5; oxidising agents

SCIENTIFIC NOTE

Recombinant peptide sourcing note: organism-expressed peptides carry the biosafety level of the expression host โ€” saccharomyces (bsl-1, safe); trypanosoma/mussel/thermophile expression requires biosafety assessment of the expression host's safety classification before cosmetic application.

Last Verified: Cosing database,r-(methionyl sh-polypeptide-10 deca recombinant multi-sequence peptide anti-aging review

Primary Sources: 2026-03-22