Common Name(s): R-(methionyl sh-polypeptide-58 decapeptide-40),r-(methionyl sh-polypeptide-58 decapeptide-40), signal peptide,anti-aging bioactive

CAS Number: N/a

DESCRIPTION

What It Does: Stimulates collagen i, iii, iv synthesis and inhibits mmp-1 collagen degradation — providing clinically measurable wrinkle reduction and skin firmness at ppm concentrations.

Why It's Used: Precision peptide pharmacology: the defined sequence targets specific receptors (tgf-β, egf, integrin, achr) with quantifiable binding kinetics enabling mechanism-based efficacy claims.

How It Works: Peptide-receptor binding → kinase cascade (map kinase, smad, or pi3k-akt) → col1a1/col3a1 upregulation and mmp-1/mmp-3 downregulation. spps synthesis provides >98% sequence purity for reproducible receptor binding.

Typically Found In: Anti-aging serums,peptide actives

TECHNICAL DETAILS

Primary Category: Active ingredient – peptide

Secondary Functions: Collagen synthesis,anti-aging

Application Areas:

Typical Concentration Range: 1–5000 ppm

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Synthetically produced via solid-phase peptide synthesis (spps).

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating at recommended concentrations.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid

Avoid Combining With: Strong acids below ph 3.5; oxidising agents

SCIENTIFIC NOTE

Peptide source is cosmetically significant: chironomid freeze-tolerance proteins, silkworm fibroin peptides, and rice prolamin peptides provide the specific amino acid sequences with documented anti-aging activity from their natural structural protein functions.

Last Verified: Cosing database,r-(methionyl sh-polypeptide-58 deca signal peptide review

Primary Sources: 2026-03-22