Common Name(s): R-(oligopeptide-126 sh-polypeptide-60 dipeptide-19 hexapeptide-40)
DESCRIPTION
What It Does: Targets multiple wrinkle formation pathways simultaneously with four complementary peptides.
Why It's Used: Used where comprehensive anti-aging requires simultaneous collagen stimulation, ecm support, and expression line reduction.
How It Works: Oligopeptide-126 (anti-aging), sh-polypeptide-60 (growth factor analog), dipeptide-19 (neuropeptide/muscle-relaxing analog), hexapeptide-40 (matrix metalloproteinase modulation) work synergistically on wrinkle formation.
Typically Found In: Advanced anti-wrinkle serums,premium anti-aging
TECHNICAL DETAILS
Primary Category: Active ingredient โ peptide
Secondary Functions: Anti-aging active,skin conditioning agent
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.001%โ0.1%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Synthetic multi-peptide complex.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Generally well tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile. ewg score: 1.
Works Well With: Other peptides,retinoids,vitamin c
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Multi-peptide complexes provide synergistic anti-aging activity by targeting different molecular pathways; combining anti-wrinkle, matrix, and neurocosmetic peptides provides comprehensive anti-aging coverage.
Last Verified: Cosing database,inci dictionary
Primary Sources: 2026-03-28