Common Name(s): R-sleeping chironomid polypeptide-2,r-sleeping chironomid polypeptide-2,chironomid-derived signal peptide,anti-aging bioactive
CAS Number: N/a
DESCRIPTION
What It Does: Stimulates collagen i, iii, iv synthesis and inhibits mmp-1 collagen degradation — providing clinically measurable wrinkle reduction and skin firmness at ppm concentrations.
Why It's Used: Precision peptide pharmacology: the defined sequence targets specific receptors (tgf-β, egf, integrin, achr) with quantifiable binding kinetics enabling mechanism-based efficacy claims.
How It Works: Peptide-receptor binding → kinase cascade (map kinase, smad, or pi3k-akt) → col1a1/col3a1 upregulation and mmp-1/mmp-3 downregulation. spps synthesis provides >98% sequence purity for reproducible receptor binding.
Typically Found In: Anti-aging serums,peptide actives
TECHNICAL DETAILS
Primary Category: Active ingredient – peptide
Secondary Functions: Collagen synthesis,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 1–5000 ppm
SOURCING & ETHICS
Vegan Status: Conditional - recombinant or synthetic; confirm no animal-derived material in expression or culture system
Halal Status: Unverified - recombinant or synthetic; confirm material origin, not sequence origin
Source Notes: Synthetically produced via solid-phase peptide synthesis (spps). [audit 2026-07-29 rev2: pass-1 miss: animal species token absent from the pass-1 list; recombinant prefix present so routed to material-origin confirmation. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating at recommended concentrations.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid
Avoid Combining With: Strong acids below ph 3.5; oxidising agents
SCIENTIFIC NOTE
Peptide source is cosmetically significant: chironomid freeze-tolerance proteins, silkworm fibroin peptides, and rice prolamin peptides provide the specific amino acid sequences with documented anti-aging activity from their natural structural protein functions.
Last Verified: 2026-03-22
Primary Sources: Cosing database,r-sleeping chironomid polypeptide-2 signal peptide review