Common Name(s): S-silkworm oligopeptide-1 sp

DESCRIPTION

What It Does: Supports anti-aging skin structure by stimulating collagen and elastin synthesis and modulating skin matrix metalloproteinase activity.

Why It's Used: Peptide sequences mimic endogenous skin communication molecules, triggering cellular responses that decline with age — restoring youthful skin structure.

How It Works: Specific amino acid sequences bind to cell surface receptors or penetrate to fibroblasts where they activate growth factor pathways, tgf-β signaling, or mmp-inhibiting mechanisms, stimulating ecm remodeling.

Typically Found In: Anti-aging serums,ampoules,eye creams,firming moisturizers

TECHNICAL DETAILS

Primary Category: Bioactive peptides

Secondary Functions: Anti-aging,skin-conditioning

Application Areas:

Typical Concentration Range: 0.001–2%

SOURCING & ETHICS

Vegan Status: No - animal-derived

Halal Status: Contested - insect-derived; jurisdiction-dependent, refer to certifier stance (region rules)

Source Notes: Contains animal-derived components (s-silkworm oligopeptide-1 sp...); not suitable for vegan formulations. [audit 2026-07-29 rev2: insect-derived; genuinely contested between certifying bodies, not resolvable by documentation. determination requires shariah-panel sign-off.]

SKIN COMPATIBILITY

Irritancy Rating: 1899-12-31 00:00:00 -0800

Sensitivity Concerns: Low sensitization potential at recommended use concentrations.

Safe for Sensitive Skin: Conditional

SAFETY & COMPATIBILITY

Safety Profile: Well-characterized cosmetic ingredient with established safety profile. generally non-irritating at typical use concentrations. suitable for leave-on and rinse-off cosmetics.

Works Well With: Retinol,vitamin c,hyaluronic acid,niacinamide

Avoid Combining With: Proteolytic enzymes (papain, bromelain); extreme ph

SCIENTIFIC NOTE

Cosmetic peptides are typically 2–10 amino acids, short enough for transdermal penetration but specific enough for receptor binding. their bioactivity depends on sequence (primary structure), lipophilization (e.g., palmitoyl modification increases skin penetration 10-fold), and resistance to skin proteases — often achieved through d-amino acid substitution or terminal modifications.

Last Verified: 2025-01-15

Primary Sources: Cosing eu database; pcpc cosmetic ingredient safety reviews; j pept sci peptide cosmetic reviews; j cosmet dermatol clinical studies