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Common Name(s): Rhegf,recombinant human epidermal growth factor

CAS Number: 62253-63-8

DESCRIPTION

What It Does: Provides direct egf receptor activation for accelerated wound healing and anti-aging cell renewal.

Why It's Used: The most clinically validated growth factor in cosmetics โ€” recombinant egf has the largest body of clinical evidence for anti-aging and wound healing acceleration of any cosmetic growth factor.

How It Works: Binds egf receptor (egfr) tyrosine kinase triggering phosphorylation cascade. egfr activation stimulates keratinocyte and fibroblast proliferation (wound healing). upregulates collagen, fibronectin, and ha synthesis. accelerates wound re-epithelialisation rate 2-3ร—.

Typically Found In: Wound healing products,premium anti-aging,post-procedure recovery

TECHNICAL DETAILS

Primary Category: Active ingredient โ€“ recombinant egf

Secondary Functions: Cell renewal,collagen stimulation,wound healing

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.0001%โ€“0.01%

SOURCING & ETHICS

Vegan Status: Yes โ€“ recombinant from yeast or e. coli expression

Halal Status: Yes

Source Notes: Biotechnology-produced (recombinant or conditioned media).

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 0/5 โ€“ non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile at cosmetic concentrations. ewg score: 1.

Works Well With: Hyaluronic acid,ceramides,peptides,antioxidants

Avoid Combining With: Avoid with harsh ahas that may denature protein structure

SCIENTIFIC NOTE

Sh-oligopeptide-1's clinical wound healing acceleration (2-3ร— faster re-epithelialisation rate at 5ฮผg/ml) was originally demonstrated in nobel laureate stanley cohen's egf research (nobel prize 1986 for egf discovery). the same growth factor that cohen purified from mouse submaxillary glands and used to study nerve and skin growth became the first recombinant protein cosmetic ingredient when biosynthetic production made it commercially accessible.

Last Verified: 2026-03-12

Primary Sources: Cosing database,cohen egf nobel lecture,rheinwald & green rhegf wound study