Common Name(s): Sialyllactose,sialyllactose,sialylated oligosaccharide,prebiotic hmo
CAS Number: N/a
DESCRIPTION
What It Does: Provides human milk oligosaccharide prebiotic selectivity for beneficial skin bacteria, pathogen anti-adhesion activity, and humectant conditioning from the trisaccharide structure.
Why It's Used: Sialyllactose is selected for its human milk oligosaccharide (hmo) microbiome-selective prebiotic identity — the sialylated structure provides bifidobacterium-selective nutrition that balances the skin microbiome analogously to its role in infant gut microbiome establishment.
How It Works: Sialyllactose: bifidobacterium fucosidase/sialidase hydrolysis → selective fermentation; sialic acid: pathogen lectin competitive inhibition → anti-adhesion protection; hydroxyl groups → humectant water binding.
Typically Found In: Microbiome skin care,baby care,sensitive skin
TECHNICAL DETAILS
Primary Category: Active ingredient – humectant
Secondary Functions: Moisture retention,hydration
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%–5%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Plant-derived or fermentation-produced.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating; suitable for sensitive skin.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Ceramides,emollients,occlusives,barrier actives
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Sialyllactose is produced by microbial fermentation — the biotechnology production route enables commercial-scale manufacture of this previously rare milk sugar.
Last Verified: 2026-03-22
Primary Sources: Cosing database,sialyllactose hmo prebiotic microbiome review