Common Name(s): Sodium carboxymethyl hyaluronate,sodium carboxymethyl hyaluronate,carboxymethyl hyaluronate,enhanced ha derivative
CAS Number: N/a
DESCRIPTION
What It Does: Provides ha's 1,000ร water retention in a modified form designed for superior delivery or extended performance โ enhanced performance versus standard sodium hyaluronate.
Why It's Used: Carboxymethyl modification provides specific advantages over sodium ha: the specific modification providing the targeted improvement for the application
How It Works: Ha backbone (ฮฒ-1,3/ฮฒ-1,4 glucuronate-glcnac) provides 1,000ร water binding from polyanionic carboxylates. chemical modification at c6-oh alters physicochemical properties โ crosslinking increases mw and reduces rinsing; acetylation raises logp for sc penetration; silanol provides si-o sc-compatible anchoring.
Typically Found In: Anti-aging hydration,barrier support,premium serums
TECHNICAL DETAILS
Primary Category: Active ingredient โ humectant
Secondary Functions: Moisture retention,hydration
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%โ2%
SOURCING & ETHICS
Vegan Status: Conditional - feedstock declaration required
Halal Status: Unverified - feedstock declaration required (plant, animal and petrochemical routes all exist)
Source Notes: Plant-derived or fermentation-produced. [audit 2026-07-29 rev2: origin-dependent: the same inci exists in plant, animal and petrochemical versions and the name does not discriminate. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; suitable for sensitive skin.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Ceramides,emollients,occlusives,barrier actives
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Modified ha clinical performance depends on modification degree and mw โ crosspolymer hydrogels provide visible moisture-film on skin (glass-skin effect); acetylated ha provides 24h hydration persistence; standard ha provides immediate intense hydration with 2โ4h duration.
Last Verified: 2026-03-22
Primary Sources: Cosing database,sodium carboxymethyl hyaluronate ha derivative review