Common Name(s): Sodium cholesteryl sulfate,sodium cholesteryl sulfate,sulfated sterol,sc desquamation regulator
CAS Number: N/a
DESCRIPTION
What It Does: Provides sc desquamation regulation through competitive steroid sulfatase inhibition — elevated cholesteryl sulfate levels reduce desquamation rate for barrier reinforcement.
Why It's Used: Sodium cholesteryl sulfate is selected as the endogenous sc desquamation modulator — the steroid sulfatase substrate that naturally controls sc shedding rate, providing exogenous supplementation to slow barrier loss in dry and compromised skin.
How It Works: Cholesteryl sulfate → steroid sulfatase competitive inhibition → reduced cholesterol release → impaired kallikrein 5/7 activation → reduced corneodesmosome cleavage → slower desquamation.
Typically Found In: Barrier care,dry skin,sc regulation
TECHNICAL DETAILS
Primary Category: Active ingredient – humectant
Secondary Functions: Moisture retention,hydration
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.05%–2%
SOURCING & ETHICS
Vegan Status: Conditional - feedstock declaration required
Halal Status: Unverified - feedstock declaration required (plant, animal and petrochemical routes all exist)
Source Notes: Plant-derived or fermentation-produced. [audit 2026-07-29 rev2: origin-dependent: the same inci exists in plant, animal and petrochemical versions and the name does not discriminate. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating; suitable for sensitive skin.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Ceramides,emollients,occlusives,barrier actives
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Cholesteryl sulfate is elevated in ichthyosis vulgaris — topical supplementation addresses the desquamation dysregulation observed in very dry barrier-compromised skin.
Last Verified: 2026-03-22
Primary Sources: Cosing database,sodium cholesteryl sulfate desquamation regulator review