Common Name(s): Sodium dermatan sulfate,sodium dermatan sulfate,glycosaminoglycan,dermatan sulfate ecm component

CAS Number: N/a

DESCRIPTION

What It Does: Provides gag-type sulfated humectancy, collagen fibril organisation through decorin proteoglycan interactions, and anti-inflammatory activity from the idoa-galnac4s repeat structure.

Why It's Used: Sodium dermatan sulfate is selected as a skin-identical extracellular matrix gag — the sulfated idoa residues provide exceptional water retention and collagen fibre spacing that ha and chondroitin sulfate cannot replicate.

How It Works: Dermatan sulfate: idoa-galnac4s repeats → h-bond water retention; decorin gag chain → collagen fibril d-spacing regulation; sulfate groups → electrostatic anti-inflammatory activity.

Typically Found In: Anti-aging,ecm support,moisturiser

TECHNICAL DETAILS

Primary Category: Active ingredient – humectant

Secondary Functions: Moisture retention,hydration

Application Areas:

Typical Concentration Range: 0.1%–5%

SOURCING & ETHICS

Vegan Status: No - animal-derived

Halal Status: Conditional - species declaration and animal origin documentation required

Source Notes: Plant-derived or fermentation-produced. [audit 2026-07-29 rev2: pass-1 miss: animal species token absent from the pass-1 token list. determination requires shariah-panel sign-off.]

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for sensitive skin.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,emollients,occlusives,barrier actives

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Dermatan sulfate is a minor gag in adult skin ecm but becomes the dominant gag in fetal skin — providing a regenerative ecm context for anti-aging formulations.

Last Verified: 2026-03-22

Primary Sources: Cosing database,sodium dermatan sulfate glycosaminoglycan review