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Common Name(s): Sodium fructoborate,sodium fructoborate,organoboron anti-aging,nf-kb inhibitor antioxidant

CAS Number: N/a

DESCRIPTION

What It Does: Provides anti-inflammatory activity through boron's nf-kb inhibition, antioxidant protection from diol-borate complex formation reducing oxidative catalysis, and skin conditioning from the fructose-borate ester's sc-compatible chemistry.

Why It's Used: Sodium fructoborate is the only natural organoboron compound with documented nf-kb inhibitory activity โ€” the boron atom's unique lewis acid geometry provides protein-boron interactions that no organic phytochemical can replicate.

How It Works: Fructoborate boron acts as a lewis acid forming reversible covalent bonds with 1,2-diol groups on proteins โ€” specifically inhibiting iฮบb kinase by boron coordination to the active site ser180/ser181 phosphorylation sites, blocking nf-ฮบb nuclear translocation. simultaneously, boron chelates catechol/diol ros-generating species reducing fenton-type radical production.

Typically Found In: Anti-inflammatory,anti-aging,antioxidant

TECHNICAL DETAILS

Primary Category: Active ingredient โ€“ antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.01%โ€“1%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 0/5 โ€“ non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Dietary boron intake is associated with reduced inflammatory markers and improved bone density โ€” sodium fructoborate provides the same organoboron chemistry for topical anti-inflammatory skin care application.

Last Verified: 2026-03-22

Primary Sources: Cosing database,sodium fructoborate organoboron nf-kb anti-inflammatory review