Common Name(s): Sodium oleoyl hyaluronate,sodium oleoyl hyaluronate,lipophilic hyaluronate,amphiphilic ha derivative
CAS Number: N/a
DESCRIPTION
What It Does: Provides hyaluronic acid humectancy with enhanced sc lipid bilayer retention from the oleoyl chain, delivering longer-lasting hydration than unmodified sodium hyaluronate.
Why It's Used: Sodium oleoyl hyaluronate is selected for its amphiphilic architecture — the oleic acid esterification anchors the ha hydrator within the sc lipid matrix for extended hydration retention unavailable from standard water-soluble ha.
How It Works: Oleoyl-ha: oleoyl c18:1 integration into sc lipid bilayer → anchors ha humectant at sc depth → prolonged water-binding retention vs surface-deposited ha.
Typically Found In: Moisturiser,barrier care
TECHNICAL DETAILS
Primary Category: Active ingredient – humectant
Secondary Functions: Moisture retention,hydration
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%–5%
SOURCING & ETHICS
Vegan Status: Conditional - feedstock declaration required
Halal Status: Unverified - feedstock declaration required (plant, animal and petrochemical routes all exist)
Source Notes: Plant-derived or fermentation-produced. [audit 2026-07-29 rev2: origin-dependent: the same inci exists in plant, animal and petrochemical versions and the name does not discriminate. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating; suitable for sensitive skin.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Ceramides,emollients,occlusives,barrier actives
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Oleoyl modification raises ha's logp from <-5 to approximately 0, transforming it from purely surface-active to amphiphilic with sc penetration capability.
Last Verified: 2026-03-22
Primary Sources: Cosing database,sodium oleoyl hyaluronate amphiphilic ha review