Common Name(s): Sodium palmitoyl proline,sodium palmitoyl proline,palmitoylated amino acid,collagen amino acid active
CAS Number: N/a
DESCRIPTION
What It Does: Provides proline amino acid substrate for collagen hydroxyproline synthesis with c16 palmitoyl chain enhancing sc lipid bilayer penetration for delivery to dermal fibroblasts.
Why It's Used: Sodium palmitoyl proline is selected for its combined collagen substrate and lipid penetration mechanism — the proline residue provides hydroxyproline precursor for collagen triple helix stability while the palmitoyl chain bypasses the sc barrier that blocks free amino acid delivery.
How It Works: Palmitoyl-proline: sc lipid bilayer partitioning (c16 chain) → fibroblast delivery → proline utilisation for hydroxyproline synthesis in procollagen gly-pro-hyp repeat → collagen triple helix stabilisation.
Typically Found In: Anti-aging,collagen support
TECHNICAL DETAILS
Primary Category: Active ingredient – peptide
Secondary Functions: Collagen synthesis,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%–3%
SOURCING & ETHICS
Vegan Status: Conditional - feedstock declaration required
Halal Status: Unverified - feedstock declaration required (plant, animal and petrochemical routes all exist)
Source Notes: Synthetically produced via solid-phase peptide synthesis (spps). [audit 2026-07-29 rev2: origin-dependent: the same inci exists in plant, animal and petrochemical versions and the name does not discriminate. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating at recommended concentrations.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid
Avoid Combining With: Strong acids below ph 3.5; oxidising agents
SCIENTIFIC NOTE
Sodium palmitoyl proline is a key active in several reference anti-aging formulas where palmitoyl amino acid complexes provide collagen amino acid delivery.
Last Verified: 2026-03-22
Primary Sources: Cosing database,sodium palmitoyl proline collagen amino acid review