Common Name(s): Sodium retinoyl hyaluronate,sodium retinoyl hyaluronate,retinoid-hyaluronate conjugate,dual-function anti-aging
CAS Number: N/a
DESCRIPTION
What It Does: Provides simultaneous rar nuclear receptor retinoid anti-aging and hyaluronate ha receptor cd44-mediated matrix hydration from a single conjugate molecule.
Why It's Used: Sodium retinoyl hyaluronate is selected for its dual-mechanism molecular architecture — the retinoic acid moiety delivers anti-aging gene activation while the hyaluronate backbone provides hydration and skin compatibility, with significantly reduced irritancy versus free retinoic acid.
How It Works: Retinoyl-ha conjugate: ha → cd44 receptor targeting → retinoid moiety released in epidermis → rar-α activation + ha hydration matrix replenishment simultaneously.
Typically Found In: Anti-aging,premium serum
TECHNICAL DETAILS
Primary Category: Active ingredient – cosmetic active
Secondary Functions: Skin conditioning
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01%–2%
SOURCING & ETHICS
Vegan Status: Conditional - feedstock declaration required
Halal Status: Unverified - feedstock declaration required (plant, animal and petrochemical routes all exist)
Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier. [audit 2026-07-29 rev2: origin-dependent: the same inci exists in plant, animal and petrochemical versions and the name does not discriminate. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.
Works Well With: Standard skincare actives
Avoid Combining With: No known significant incompatibilities
SCIENTIFIC NOTE
Sodium retinoyl hyaluronate provides the retinoid activity of retinoic acid with a skin tolerance profile comparable to retinyl esters — the hyaluronate conjugate suppresses the irritation cascade.
Last Verified: 2026-03-22
Primary Sources: Cosing database,sodium retinoyl hyaluronate retinoid conjugate review