Common Name(s): Spiraeoside,spiraeoside,quercetin glucoside,anti-inflammatory flavonoid
CAS Number: N/a
DESCRIPTION
What It Does: Provides quercetin flavonoid antioxidant and nf-kb anti-inflammatory activity with improved water solubility and bioavailability from the 4'-glucoside modification.
Why It's Used: Spiraeoside is selected as a water-soluble quercetin glycoside — the 4'-glucoside provides full aqueous solubility for high-concentration incorporation in water-based formulas while retaining quercetin's potent antioxidant and anti-inflammatory pharmacology.
How It Works: Spiraeoside → glycosidase hydrolysis → quercetin → catechol catechin ring radical scavenging + nf-kb inhibition; 4'-glucoside: improved aqueous solubility vs free quercetin (logp -1.5 vs +1.5).
Typically Found In: Antioxidant,anti-inflammatory
TECHNICAL DETAILS
Primary Category: Active ingredient – antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.05%–2%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Spiraeoside provides better water solubility than rutin (quercetin-3-rutinoside) — the 4' position glucosylation minimises steric interference with the antioxidant catechol ring.
Last Verified: 2026-03-22
Primary Sources: Cosing database,spiraeoside quercetin glycoside antioxidant review