Common Name(s): Staphylococcus epidermidis,staphylococcus epidermidis,commensal skin bacterium,probiotic active

CAS Number: N/a

DESCRIPTION

What It Does: Provides s. epidermidis-characteristic 6-hap antimicrobial peptide activity against s. aureus, serine protease exfoliation, and skin microbiome balance restoration.

Why It's Used: Staphylococcus epidermidis is selected as the skin's primary beneficial commensal — its 6-hap production inhibits s. aureus colonisation implicated in atopic dermatitis, providing a microbiome-based anti-inflammatory mechanism that conventional anti-inflammatories cannot replicate.

How It Works: S. epidermidis: 6-hap production → s. aureus growth inhibition; serine protease → sc desquamation; fatty acid production → slightly acidic skin ph maintenance; biofilm eps → barrier support.

Typically Found In: Microbiome skin care,sensitive skin,anti-acne

TECHNICAL DETAILS

Primary Category: Active ingredient – skin microbiome support

Secondary Functions: Microbiome balance,prebiotic effect

Application Areas:

Typical Concentration Range: 0.1%–5%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Fermentation-derived or plant-extracted.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; beneficial for sensitive skin.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,niacinamide,soothing actives

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Live s. epidermidis requires preservation management — lysate and filtrate formats provide preserved formats while retaining most of the commensal bacterium's postbiotic benefits.

Last Verified: 2026-03-22

Primary Sources: Cosing database,staphylococcus epidermidis commensal probiotic review