Common Name(s): Tetracarboxymethyl palmitoyl dipeptide-12,tetracarboxymethyl palmitoyl dipeptide-12,lipopeptide,acylated signal peptide
CAS Number: N/a
DESCRIPTION
What It Does: Provides the peptide's receptor signal sequence with palmitoyl chain enhancement of percutaneous penetration through sc lipid bilayer solubilisation.
Why It's Used: Tetracarboxymethyl palmitoyl dipeptide-12 is selected for its palmitoyl acylation — the fatty acid chain logarithmically increases sc partitioning, raising active peptide concentration at dermal receptors for superior anti-aging outcome.
How It Works: Palmitoyl-peptide: partition into sc lipid bilayer (logp boost ~2–3 units) → follicular and intercellular diffusion → peptide receptor activation in dermis.
Typically Found In: Anti-aging,serum,eye care
TECHNICAL DETAILS
Primary Category: Active ingredient – peptide
Secondary Functions: Collagen synthesis,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.001%–2%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Synthetically produced via solid-phase peptide synthesis (spps).
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating at recommended concentrations.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid
Avoid Combining With: Strong acids below ph 3.5; oxidising agents
SCIENTIFIC NOTE
Palmitoyl chain length determines sc retention time — c16 palmitoyl provides the optimal balance of penetration and payload delivery.
Last Verified: 2026-03-22
Primary Sources: Cosing database,tetracarboxymethyl palmitoyl dipeptide-1 lipopeptide review