Common Name(s): Thiamine nitrate,thiamine nitrate,vitamin b1,thiamine coenzyme metabolic active

CAS Number: N/a

DESCRIPTION

What It Does: Provides vitamin b1 tpp cofactor for oxidative decarboxylation reactions in skin cell energy metabolism, with the diphosphate form providing direct active coenzyme activity.

Why It's Used: Thiamine nitrate is selected for vitamin b1 energy cofactor activity — tpp is a non-exchangeable coenzyme for pyruvate dehydrogenase, the rate-limiting step in carbohydrate energy metabolism that fuels keratinocyte proliferation and sc renewal.

How It Works: Thiamine → thiamine kinase → thiamine monophosphate → thiamine diphosphate (tpp); tpp + apoenzyme → pyruvate dehydrogenase complex → acetyl-coa production → tca cycle energy.

Typically Found In: Anti-aging,skin conditioning

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Typical Concentration Range: 0.01%–2%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Thiamine diphosphate provides direct coenzyme activity without requiring cellular phosphorylation — providing faster onset than free thiamine supplementation.

Last Verified: 2026-03-22

Primary Sources: Cosing database,thiamine nitrate vitamin b1 thiamine review