Common Name(s): Tissue transglutaminase,tgase,factor xiiia-like
CAS Number: 80146-85-6
DESCRIPTION
What It Does: Supports cornified envelope formation by crosslinking structural barrier proteins for improved barrier integrity.
Why It's Used: Advanced barrier support ingredient targeting the enzymatic crosslinking step of cornified envelope formation – relevant for eczema and barrier-deficient conditions.
How It Works: Catalyzes isopeptide bond formation between glutamine and lysine residues in involucrin, loricrin, and other cornified envelope proteins. tgase-1 and tgase-3 isoforms in the epidermis catalyze sequential crosslinking steps forming the structural cornified envelope scaffold.
Typically Found In: Barrier repair products,eczema treatments,advanced skin care
TECHNICAL DETAILS
Primary Category: Active ingredient – barrier crosslinking enzyme
Secondary Functions: Cornified envelope formation,barrier protein crosslinking
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.001%–0.05%
SOURCING & ETHICS
Vegan Status: Conditional – from microbial fermentation (streptoverticillium)
Halal Status: Yes – microbial source
Source Notes: Plant-derived (papaya, pineapple) or fermentation-derived.
SKIN COMPATIBILITY
Irritancy Rating: 2/5 – low to moderate
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Patch test recommended; potential for enzymatic sensitization.
Safe for Sensitive Skin: Use with caution – potential sensitization
SAFETY & COMPATIBILITY
Safety Profile: Safe at cosmetic concentrations. patch test recommended. ewg score: 1–2.
Works Well With: Ahas (synergistic),hyaluronic acid,ceramides
Avoid Combining With: High concentrations on sensitive or compromised skin
SCIENTIFIC NOTE
Transglutaminase mutations cause lamellar ichthyosis – a severe barrier deficiency disease – demonstrating the enzyme's critical role in barrier formation. tgase-1 activity generates the primary covalent bonds holding the cornified envelope together, making it the most mechanistically direct approach to barrier protein support available.
Last Verified: 2026-03-12
Primary Sources: Cosing database,steinert & marekov cornified envelope review