Common Name(s): Zederone,zederone,ginger family sesquiterpene,anti-inflammatory ketone

CAS Number: N/a

DESCRIPTION

What It Does: Provides guaiane sesquiterpene ketone anti-inflammatory activity through nf-kb inhibition and prostaglandin biosynthesis modulation.

Why It's Used: Zederone is selected for the unique guaiane sesquiterpene ketone anti-inflammatory scaffold of curcuma zedoaria — providing distinct anti-inflammatory pharmacology from the curcuminoids of standard turmeric, complementing the curcumin mechanism with sesquiterpene nf-kb modulation.

How It Works: Zederone bicyclic guaiane → nf-kb p65 nuclear translocation inhibition → reduced il-1β/il-6/tnf-α; alpha,beta-unsaturated ketone → michael acceptor activity; anti-proliferative via cdk inhibition.

Typically Found In: Anti-inflammatory,anti-aging

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Typical Concentration Range: 0.05%–2%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Zederone is the pharmacologically active sesquiterpene marker compound of curcuma zedoaria — standardisation to zederone content is the quality marker for white turmeric extracts.

Last Verified: 2026-03-22

Primary Sources: Cosing database,zederone guaiane sesquiterpene curcuma zedoaria review