Common Name(s): Zinc acetylmethionate,zinc acetylmethionate,zinc salt,bioavailable zinc active

CAS Number: N/a

DESCRIPTION

What It Does: Provides bioavailable zn²⁺ for copper-zinc sod antioxidant enzyme cofactor, mmp collagenase regulatory activity, 5-alpha reductase sebum pathway inhibition, and p53-related wound healing gene activation.

Why It's Used: Zinc acetylmethionate is selected as a bioavailable zinc form — the acetylmethionate ligand provides improved aqueous solubility and skin absorption over zinc oxide/sulfate, delivering zn²⁺ to enzyme cofactor sites where zinc deficiency drives antioxidant enzyme underactivity, sebum excess, or wound healing impairment.

How It Works: Zinc acetylmethionate: aqueous dissolution → zn²⁺ release → cu-zn sod cofactor + 5α-reductase inhibition → sebum reduction + mmp regulatory activity + wound healing p53 activation.

Typically Found In: Anti-acne,antioxidant,wound healing

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Typical Concentration Range: 0.1%–5%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Zinc bioavailability varies significantly by salt — zinc acetylmethionate provides superior skin penetration versus inorganic zinc salts for enzyme cofactor delivery.

Last Verified: 2026-03-22

Primary Sources: Cosing database,zinc acetylmethionate bioavailable zinc review