
Highlights
WHAT IS IT?
Spot treatment lotion with 19 ingredients
FEATURES
Targets acne spots, soothes and heals, prevents pimples
BEST FOR
Acne-prone skin
CHECKS
Free of sulfates, parabens
Who Is It For?
Adults With Acne ConcernsWhat Does It Help With?
Blemishes Acne Deep Unsurfaced PimplesBudget
AffordableHow To Use
Which routine should it be used in?
Instructions:
Key Information
What COSRX Official Says
Product Description:
Acne spot care that's never been so fun! Spot treatment to care for your blemishes overnight. Formulated with Calamine and Vitamin B12, this drying lotion cares for the acne spots while clearing your skin. Calamine, Zinc Oxide, Salicylic Acid, and Centella works to cool and calm the area of concern.
About the Brand:
Ingredients Overview
Ingredients List
ALCOHOL, WATER, CALAMINE, GLYCERIN, TITANIUM DIOXIDE, ZINC OXIDE, DIMETHYL SULFONE, SILICA, BUTYLENE GLYCOL, SALICYLIC ACID, SALIX ALBA (WILLOW) BARK EXTRACT, COLLOIDAL SULFUR, ETHYL HEXANEDIOL, ACACIA SENEGAL GUM, 1,2-HEXANEDIOL, CAMPHOR, CYANOCOBALAMIN, MADECASSIC ACID, ASIATICOSIDE, ASIATIC ACID
Key Ingredients
Calamine, Zinc Oxide, Salicylic Acid, Centella (Madecassic Acid, Asiaticoside, Asiatic Acid)
Ingredients Details
Alcohol
Common Name(s): Alcohol,cosmetic active,functional ingredient
CAS Number: N/a
DESCRIPTION
What It Does: Delivers characteristic cosmetic function at recommended use concentration.
Why It's Used: Selected for functional contribution and formulation compatibility supported by cosmetic science and regulatory safety data.
How It Works: Works through the mechanism of its molecular class as documented in peer-reviewed cosmetic literature.
Typically Found In: Skin care formulations
TECHNICAL DETAILS
Primary Category: Active ingredient โ cosmetic active
Secondary Functions: Skin conditioning
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%โ10%
SOURCING & ETHICS
Vegan Status: Conditional
Halal Status: Yes
Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Well-tolerated by most skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile at recommended concentrations. ewg score: 1โ2.
Works Well With: Standard skincare actives
Avoid Combining With: No known significant incompatibilities
SCIENTIFIC NOTE
Alcohol has an established safety profile within the cosmetic regulatory framework at standard use concentrations.
Last Verified: Cosing database,alcohol technical literature
Primary Sources: 2026-03-12
Butylene Glycol
Common Name(s): 1,3-butanediol,bg,1,3-butylene glycol
CAS Number: 107-88-0
DESCRIPTION
What It Does: Provides humectant hydration and active ingredient solubilization with excellent skin feel.
Why It's Used: Preferred glycol humectant in premium and k-beauty formulations for superior skin feel vs propylene glycol with equivalent functionality.
How It Works: Two hydroxyl groups at 1,3-positions provide water binding and solvent activity. better tolerated than propylene glycol with minimal sensitization risk. 4-carbon backbone provides slightly greater hydrophobic character enabling dissolution of less polar actives vs pg.
Typically Found In: Toners,essences,serums,k-beauty formulas
TECHNICAL DETAILS
Primary Category: Functional ingredient โ glycol humectant
Secondary Functions: Tewl reduction,skin plumping
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 1%โ10%
SOURCING & ETHICS
Vegan Status: Yes โ synthetic
Halal Status: Yes
Source Notes: Synthetic or naturally derived. excellent aqueous solubility.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; suitable for all skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Ceramides,emollients,occlusives,glycerin,hyaluronic acid
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
K-beauty's preference for butylene glycol over propylene glycol is driven by two factors: bg's superior skin feel (less tacky than pg's higher viscosity) and its lower sensitization potential (1,3-bg has better spatial distribution of hydroxyl groups that reduces protein interaction vs pg's 1,2-position oh groups).
Last Verified: Cosing database,cir safety assessment
Primary Sources: 2026-03-12
Calamine
Common Name(s): Calamine,cosmetic active,functional ingredient
CAS Number: N/a
DESCRIPTION
What It Does: Delivers characteristic cosmetic function at recommended use concentration.
Why It's Used: Selected for functional contribution and formulation compatibility supported by cosmetic science and regulatory safety data.
How It Works: Works through the mechanism of its molecular class as documented in peer-reviewed cosmetic literature.
Typically Found In: Skin care formulations
TECHNICAL DETAILS
Primary Category: Active ingredient โ cosmetic active
Secondary Functions: Skin conditioning
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%โ10%
SOURCING & ETHICS
Vegan Status: Conditional
Halal Status: Yes
Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Well-tolerated by most skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile at recommended concentrations. ewg score: 1โ2.
Works Well With: Standard skincare actives
Avoid Combining With: No known significant incompatibilities
SCIENTIFIC NOTE
Calamine has an established safety profile within the cosmetic regulatory framework at standard use concentrations.
Last Verified: Cosing database,calamine technical literature
Primary Sources: 2026-03-12
Dimethyl Sulfone
Common Name(s): Msm,organic sulfur,anti-inflammatory sulfur
CAS Number: 67-71-0
DESCRIPTION
What It Does: Provides anti-inflammatory organic sulfur for skin strengthening from msm.
Why It's Used: Bioavailable organic sulfur anti-inflammatory โ msm provides the sulfur required for keratin disulfide bonding and collagen sulfur amino acids alongside anti-inflammatory activity, making it a functional sulfur supplement for both structural skin proteins and inflammatory skin conditions.
How It Works: (ch3)2so2: highly bioavailable sulfur. anti-inflammatory: nf-kb inhibition + oxidative stress reduction. keratin: disulfide bond sulfur source. collagen: methionine + cysteine content. anti-acne: anti-inflammatory + antimicrobial. oral supplement: joint pain, anti-inflammatory. topical: skin brightening + anti-inflammatory.
Typically Found In: Anti-inflammatory skin care,strengthening products
TECHNICAL DETAILS
Primary Category: Active ingredient โ cosmetic active
Secondary Functions: Skin conditioning
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 1%โ10%
SOURCING & ETHICS
Vegan Status: Yes โ synthetic
Halal Status: Yes
Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Well-tolerated by most skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile at recommended concentrations. ewg score: 1โ2.
Works Well With: Standard skincare actives
Avoid Combining With: No known significant incompatibilities
SCIENTIFIC NOTE
Msm sulfur bioavailability: msm's dimethyl sulfone form provides sulfur without the digestive hydrogen sulfide issues of inorganic sulfates. topically, msm penetrates sc readily from low mw (94 da) + high oil-water partition compatibility, delivering sulfur to dermis for keratin/collagen synthesis cofactor function. this combination of sc penetration + sulfur bioavailability makes msm the most practical topical sulfur supplement.
Last Verified: Cosing database,msm anti-inflammatory review
Primary Sources: 2026-03-12